Increased infiltrated macrophages in benign prostatic hyperplasia (BPH): role of stromal androgen receptor in macrophage-induced prostate stromal cell proliferation.

@article{Wang2012IncreasedIM,
  title={Increased infiltrated macrophages in benign prostatic hyperplasia (BPH): role of stromal androgen receptor in macrophage-induced prostate stromal cell proliferation.},
  author={Xiaohai Wang and Wen-Jye Lin and Kouji Izumi and Qi Chuan Jiang and Kuo-Pao Lai and Defeng Xu and Lei-Ya Fang and Tianjing Lu and Lei Li and Shujie Xia and Chawnshang Chang},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 22},
  pages={
          18376-85
        }
}
Infiltrated macrophages may play important roles in the development and progression of benign prostatic hyperplasia (BPH), but the underlying mechanisms remain largely unknown. We found increased macrophages infiltration in human and mouse BPH tissues. By establishing a co-culture transwell system, we found increased migration of macrophages and proliferation of prostate stromal cells during co-culture. Importantly, stromal androgen receptor (AR) could enhance the migration of macrophages and… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 26 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 49 REFERENCES

Chemokines and BPH/LUTS.

  • Differentiation; research in biological diversity
  • 2011
VIEW 2 EXCERPTS

Androgen receptor promotes hepatitis AR Promotes Stromal Cell Proliferation via CCL3 18384 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

M. H. Wu, W. L. Ma, +6 authors C. Chang
  • MAY 25,
  • 2010
VIEW 1 EXCERPT