Increased incidence of urinary matrix metalloproteinases as predictors of disease in pediatric patients with inflammatory bowel disease.

@article{Manfredi2008IncreasedIO,
  title={Increased incidence of urinary matrix metalloproteinases as predictors of disease in pediatric patients with inflammatory bowel disease.},
  author={Michael A. Manfredi and David Zurakowski and Paul A Rufo and Thomas R Walker and Victor L. Fox and Marsha A Moses},
  journal={Inflammatory bowel diseases},
  year={2008},
  volume={14 8},
  pages={
          1091-6
        }
}
BACKGROUND Matrix metalloproteinases (MMPs) are a family of metal-dependent enzymes responsible for the degradation and remodeling of extracellular matrix and basement membrane proteins that occurs during both normal physiologic activity and disease. It has been suggested that MMPs may also play a role in the pathogenesis of inflammatory bowel disease (IBD) by mediating mucosal breakdown in response to an enhanced inflammatory cascade. We previously demonstrated that elevated urinary MMP levels… CONTINUE READING

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