Increased incidence of non-tasters of phenylthiocarbamide among congenital athyreotic cretins.

Abstract

The incidence of nontasters for phenylthiocarbamide was found to be significantly higher in 27 athyreotic cretins than in normal adults and children. A significant increase of nontasters among the parents and siblings of these cretins was also found. These findings are discussed in relation to maldevelopment of the fetal thyroid in nontaster genotypes. 

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