Increased incidence of neoplasia of the digestive tract in men with persistent activation of the coagulant pathway.


BACKGROUND Thrombin promotes angiogenesis and cell proliferation in cancer. Whether thrombin turnover influences cancer incidence is unknown. OBJECTIVES To explore the relation between the status of the coagulant pathway and cancer incidence by population survey. METHODS Of 4,009 middle-aged men clinically free of malignancy, 3052 (76.1%) were recruited… (More)


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