Increased incidence of acute graft-versus-host disease with the continuous infusion of cyclosporine A compared to twice-daily infusion

@article{Ogawa2004IncreasedIO,
  title={Increased incidence of acute graft-versus-host disease with the continuous infusion of cyclosporine A compared to twice-daily infusion},
  author={Natsu Ogawa and Yoshinobu Kanda and Momoyo Matsubara and Yoshinobu Asano and Masahiro Nakagawa and Mamiko Sakata-Yanagimoto and Koji Kandabashi and Koji Izutsu and Yoichi Imai and Akira Hangaishi and Mineo Kurokawa and Shiho Tsujino and Seishi Ogawa and Kazunari Aoki and Shigeru Chiba and Toru Motokura and Hisamaru Hirai},
  journal={Bone Marrow Transplantation},
  year={2004},
  volume={33},
  pages={549-552}
}
Summary:We retrospectively compared the incidence of acute graft-versus-host disease (GVHD) before and after September 1999, when we changed the mode of cyclosporine A (CsA) administration from twice-daily infusions (TD) (n=58) to continuous infusion (CIF) (n=71). The incidence of grade II–IV acute GVHD in the CIF group (56%) was significantly higher than that in the TD group (27%, P=0.00022). Multivariate analysis identified only two independent significant risk factors for the development of… CONTINUE READING

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