Increased in vivo immunological potency of HB-110, a novel therapeutic HBV DNA vaccine, by electroporation

  title={Increased in vivo immunological potency of HB-110, a novel therapeutic HBV DNA vaccine, by electroporation},
  author={Chae Young Kim and Eun Sung Kang and Seon B. Kim and Han Eol Kim and Jae Hoon Choi and Dong Sop Lee and Se Jin Im and Se Hwan Yang and Young Chul Sung and Byong Moon Kim and Byung-Gee Kim},
  journal={Experimental & Molecular Medicine},
Pulse-induced permeabilization of cellular membranes, generally referred to as electroporation (EP), has been used for years as a tool to increase macromolecule uptake in tissues, including nucleic acids, for gene therapeutic applications, and this technique has been shown to result in improved immunogenicity. In this study, we assessed the utility of EP as a tool to improve the efficacy of HB-110, a novel therapeutic DNA vaccine against chronic hepatitis B, now in phase 1 of clinical study in… CONTINUE READING
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Effect of Plasmid DNA Vaccine Design and In vivo Electroporation on the resulting Vaccine - Specific Immune Responses in Resus Macaques

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