Increased in vitro release of interferon-gamma from ampicillin-stimulated peripheral blood mononuclear cells in Stevens-Johnson syndrome.

@article{Yoshimura2004IncreasedIV,
  title={Increased in vitro release of interferon-gamma from ampicillin-stimulated peripheral blood mononuclear cells in Stevens-Johnson syndrome.},
  author={Tomoaki Yoshimura and Emi Hamaguchi and Eiseki Usami and Keiji Nakashima and Mayumi Kawaguchi and N Suzuki and Yoshimi Okamoto and Toshiya Nakao and Futoshi Yamazaki},
  journal={Biological \& pharmaceutical bulletin},
  year={2004},
  volume={27 6},
  pages={
          929-31
        }
}
Stevens-Johnson syndrome (SJS) was diagnosed in a 39-year-old woman, treated with ampicillin (4000-8000 mg daily), phenytoin (250 mg daily), and furosemide (20-40 mg daily) for 25, 21, and 20 d, respectively, before the appearance of the eruption. The lymphocyte stimulation test with the MTT [3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyl tetrazolium bromide] assay on ampicillin, phenytoin, and furosemide showed a low value of stimulation index, which indicated negative reactivity. An in vitro IFN… 
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