Increased in vitro histamine responses in human small airways smooth muscle from patients with chronic obstructive pulmonary disease.

We tested the hypothesis that abnormal responses of airway smooth muscle contribute to the pathogenesis of airway obstruction in chronic obstructive pulmonary disease (COPD). For this purpose, lung tissue from 10 patients with and 10 patients without COPD was obtained during thoracotomies. Lung function was measured preoperatively. The in vitro responses of… CONTINUE READING