Increased in vitro and in vivo transgene expression levels mediated through cis-acting elements.

@article{Johansen2003IncreasedIV,
  title={Increased in vitro and in vivo transgene expression levels mediated through cis-acting elements.},
  author={Jens Johansen and Jens Torn\oe and Arne M\oller and Teit E. Johansen},
  journal={The journal of gene medicine},
  year={2003},
  volume={5 12},
  pages={1080-9}
}
BACKGROUND Gene therapy for neurodegenerative diseases depends critically on the vector system to direct sustained and stable expression of the transgene. It is, however, a commonly observed phenomenon that transgene expression from currently available vectors is down-regulated following ex vivo gene transfer to the central nervous system (CNS). In an attempt to circumvent this problem, we have systematically evaluated the potential of different cis-acting elements to increase and stabilize… CONTINUE READING
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