Increased importin-beta-dependent nuclear import of the actin modulating protein CapG promotes cell invasion.

@article{Corte2004IncreasedIN,
  title={Increased importin-beta-dependent nuclear import of the actin modulating protein CapG promotes cell invasion.},
  author={Veerle De Corte and Katrien Van Impe and Erik A. Bruyneel and Ciska Boucherie and Marc Mareel and Jo{\"e}l Vandekerckhove and Jan Gettemans},
  journal={Journal of cell science},
  year={2004},
  volume={117 Pt 22},
  pages={
          5283-92
        }
}
CapG (gCap39) is a ubiquitous gelsolin-family actin modulating protein involved in cell signalling, receptor-mediated membrane ruffling, phagocytosis and motility. CapG is the only gelsolin-related actin binding protein that localizes constitutively to both nucleus and cytoplasm. Structurally related proteins like severin and fragmin are cytoplasmic because they contain a nuclear export sequence that is absent in CapG. Increased CapG expression has been reported in some cancers but a causal… CONTINUE READING
Highly Cited
This paper has 25 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 55 references

Nuclear actin and protein 4.1: essential interactions during nuclear assembly in vitro.

Proceedings of the National Academy of Sciences of the United States of America • 2003
View 1 Excerpt
Highly Influenced