Increased immunopotency of monocyte derived dendritic cells from patients with optic neuritis is inhibited in vitro by simvastatin.

@article{Tsakiri2010IncreasedIO,
  title={Increased immunopotency of monocyte derived dendritic cells from patients with optic neuritis is inhibited in vitro by simvastatin.},
  author={Anna Tsakiri and Dimitris Tsiantoulas and Jette L. Frederiksen and Inge Marie Svane},
  journal={Experimental neurology},
  year={2010},
  volume={221 2},
  pages={320-8}
}
Multiple sclerosis (MS) is an autoimmune disease where myelin-reactive lymphocytes and their activation depend on interactions with antigen presenting cells (APCs). Dendritic cells (DC) are professional APCs dependent on maturation to attain full T-cell priming capacity. The immunomodulatory properties of simvastatin influence the function of both T cells and APCs and could thus be a potential therapy for MS. The phenotype of myeloid DC in untreated patients with monosymptomatic optic neuritis… CONTINUE READING