Increased hypothalamic neuropeptide Y messenger RNA levels in two rat models of diabetes.

@article{Jones1992IncreasedHN,
  title={Increased hypothalamic neuropeptide Y messenger RNA levels in two rat models of diabetes.},
  author={Peter Martin Jones and Anne Pierson and G. Ishmael Williams and Mohammad A. Ghatei and Stephen R. Bloom},
  journal={Diabetic medicine : a journal of the British Diabetic Association},
  year={1992},
  volume={9 1},
  pages={76-80}
}
Elevated levels of immunoreactive hypothalamic neuropeptide Y have recently been reported both in streptozotocin-induced diabetic rats and in the spontaneously diabetic BB rat. We have measured the levels of neuropeptide Y encoding messenger ribonucleic acid (mRNA) in both of these rat models to determine whether an increase in neuropeptide Y gene expression is a contributory factor to the increases in hypothalamic neuropeptide Y immunoreactive peptide content. In the hypothalami of both the… CONTINUE READING