Increased hypothalamic angiotensin-(1–7) levels in rats with aortic coarctation-induced hypertension

@article{Gironacci2007IncreasedHA,
  title={Increased hypothalamic angiotensin-(1–7) levels in rats with aortic coarctation-induced hypertension},
  author={Mariela Mercedes Gironacci and K. Bridget Brosnihan and Carlos M. Ferrario and Susana Beatriz Gorzalczany and Mar{\'i}a A. Lopez Verrilli and Mariano M. Pascual and Carlos Alberto Taira and Clara Pẽna},
  journal={Peptides},
  year={2007},
  volume={28},
  pages={1580-1585}
}
Since angiotensin (Ang) (1-7) injected into the brain blocked Ang II pressor actions in rats made hypertensive by aortic coarctation (CH), we examined systemic and tissue angiotensin peptide levels, specifically concentrating on the hypothalamic Ang-(1-7) levels. Plasma, heart and kidney isolated from CH rats showed increased levels of Ang I, Ang II and Ang-(1-7) compared with the normotensive group, with Ang II being the predominant peptide in heart and kidney. In the hypothalamus, equimolar… Expand
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