Increased hydrogen peroxide concentration in the exhaled breath condensate of stable COPD patients after nebulized N-acetylcysteine.

@article{Rysz2007IncreasedHP,
  title={Increased hydrogen peroxide concentration in the exhaled breath condensate of stable COPD patients after nebulized N-acetylcysteine.},
  author={Jacek Rysz and Robert A. Stolarek and Rafal Luczyński and Agata Sarniak and Anna J. Wlodarczyk and Marek Kasielski and Dariusz Nowak},
  journal={Pulmonary pharmacology & therapeutics},
  year={2007},
  volume={20 3},
  pages={281-9}
}
BACKGROUND The oxidative burden in the airways is a hallmark of chronic obstructive pulmonary disease (COPD). AIMS This prospective, cross-over, placebo (PL)-controlled study was designed to investigate the effect of N-acetyl-l-cysteine (NAC) on hydrogen peroxide (H(2)O(2)), nitrites and nitrates (NO(2)(-)+NO(3)(-)), and thiol (RSH) concentrations in exhaled breath condensate (EBC) in stable COPD patients (n=19, aged 52.6+/-15.6 years, 10 females, mean FEV(1) 95.2+/-23.8%, FEV(1)/FVC 69.1… CONTINUE READING