Increased hyaluronan fragmentation during pulmonary ischemia.

@article{Eldridge2011IncreasedHF,
  title={Increased hyaluronan fragmentation during pulmonary ischemia.},
  author={Lindsey Eldridge and Aigul Moldobaeva and Elizabeth M Wagner},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2011},
  volume={301 5},
  pages={
          L782-8
        }
}
Hyaluronan (HA), a glycosaminoglycan critical to the lung extracellular matrix, has been shown to dissociate into low-molecular-weight (LMW) HA fragments following exposure to injurious stimuli. In the present study we questioned whether lung HA changed during ischemia and whether changes had an effect on subsequent angiogenesis. After left pulmonary artery ligation (LPAL) in mice, we analyzed left lung homogenates immediately after the onset of ischemia (0 h) and intermittently for 14 days… CONTINUE READING

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