Increased human immunodeficiency virus type 1 (HIV-1) env compartmentalization in the presence of HIV-1-associated dementia.

@article{Ritola2005IncreasedHI,
  title={Increased human immunodeficiency virus type 1 (HIV-1) env compartmentalization in the presence of HIV-1-associated dementia.},
  author={Kimberly D. Ritola and Kevin VV. Robertson and Susan A. Fiscus and Colin Hall and R. Swanstrom},
  journal={Journal of virology},
  year={2005},
  volume={79 16},
  pages={10830-4}
}
The human immunodeficiency virus type 1 (HIV-1) surface Env protein has been implicated in the development of HIV-1-associated dementia (HAD). HIV-1 env diversity was analyzed by heteroduplex tracking assay in 27 infected subjects with various neurological statuses. env compartmentalization between the blood and cerebral spinal fluid (CSF) was apparent with all neurological categories. However, in subjects with HAD, significantly more CSF virus was represented by CNS-unique env variants… CONTINUE READING
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