Increased histidine decarboxylase expression during in vitro monocyte maturation; a possible role of endogenously synthesised histamine in monocyte/macrophage differentiation

@article{Lszl2001IncreasedHD,
  title={Increased histidine decarboxylase expression during in vitro monocyte maturation; a possible role of endogenously synthesised histamine in monocyte/macrophage differentiation},
  author={V Moln{\'a}r L{\'a}szl{\'o} and Gregor Rothe and Hargita Hegyesi and J{\'o}sef Szeber{\'e}nyi and E. Orso{\'o} and Gerd Schmitz and Andr{\'a}s Falus},
  journal={Inflammation Research},
  year={2001},
  volume={50},
  pages={428-434}
}
Objective: In this study the expression of histidine decarboxylase (HDC), the pivotal enzyme in histamine formation and the effect of endogenously produced histamine on differentiation antigens was examined during in vitro differentiation of human monocytes. Material and treatment: Human elutriated monocytes from healthy volunteers were incubated with macrophage colony stimulating factor (M-CSF) and the expression of HDC was followed at both mRNA and protein levels. To study the possible… CONTINUE READING

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