Increased hexosaminidase activity in antipsychotic-induced extrapyramidal side effects: Possible association with higher occurrence in bipolar disorder patients

@article{Tunca2008IncreasedHA,
  title={Increased hexosaminidase activity in antipsychotic-induced extrapyramidal side effects: Possible association with higher occurrence in bipolar disorder patients},
  author={Z. Tunca and H. Resmi and H. A. Ozkara and G{\"o}nenç Ciliv and G. Ergor},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2008},
  volume={32},
  pages={1214-1220}
}
  • Z. Tunca, H. Resmi, +2 authors G. Ergor
  • Published 2008
  • Psychology, Medicine
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • Dystonic movements and Parkinsonism are frequently seen in gangliosidoses and these conditions have been reported to modify dopaminergic plasticity. We investigated whether the activity of hexosaminidase, a type-two ganglioside (GM2) degrading enzyme, correlates with drug-induced extrapyramidal system (EPS) side effects in psychiatric patients. We compared hexosaminidase activity in the lymphocytes of 29 EPS-positive patients, 13 EPS-negative patients, and 30 healthy volunteers. The activities… CONTINUE READING
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