Increased hepcidin in transferrin-treated thalassemic mice correlates with increased liver BMP2 expression and decreased hepatocyte ERK activation.

@article{Chen2016IncreasedHI,
  title={Increased hepcidin in transferrin-treated thalassemic mice correlates with increased liver BMP2 expression and decreased hepatocyte ERK activation.},
  author={Huiyong Chen and Tenzin Choesang and Huihui Li and Shuming Sun and Petra Pham and Weili Bao and Maria Feola and Mark E. Westerman and Guiyuan Li and Antonia Follenzi and Lionel Blanc and Stefano Rivella and Robert E. Fleming and Yelena Z. Ginzburg},
  journal={Haematologica},
  year={2016},
  volume={101 3},
  pages={297-308}
}
Iron overload results in significant morbidity and mortality in β-thalassemic patients. Insufficient hepcidin is implicated in parenchymal iron overload in β-thalassemia and approaches to increase hepcidin have therapeutic potential. We have previously shown that exogenous apo-transferrin markedly ameliorates ineffective erythropoiesis and increases hepcidin expression in Hbb(th1/th1) (thalassemic) mice. We utilize in vivo and in vitro systems to investigate effects of exogenous apo-transferrin… CONTINUE READING
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