Increased hepatocellular protein carbonylation in human end-stage alcoholic cirrhosis.

@article{Shearn2015IncreasedHP,
  title={Increased hepatocellular protein carbonylation in human end-stage alcoholic cirrhosis.},
  author={Colin T Shearn and David J Orlicky and Laura M. Saba and Alisabeth H. Shearn and Dennis R. Petersen},
  journal={Free radical biology & medicine},
  year={2015},
  volume={89},
  pages={
          1144-53
        }
}
  • Colin T Shearn, David J Orlicky, +2 authors Dennis R. Petersen
  • Published 2015
  • Medicine, Chemistry
  • Free radical biology & medicine
  • OBJECTIVE Oxidative stress is a significant contributing factor in the pathogenesis of alcoholic liver disease (ALD). In the murine models of chronic alcohol consumption, induction of oxidative stress results in increased peroxidation of polyunsaturated fatty acids to form highly reactive electrophilic α/β unsaturated aldehydes that post-translationally modify proteins altering activity. Data are presented here suggesting that oxidative stress and the resulting carbonylation of hepatic proteins… CONTINUE READING

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