Increased hepatitis C virus (HCV)-specific CD4+CD25+ regulatory T lymphocytes and reduced HCV-specific CD4+ T cell response in HCV-infected patients with normal versus abnormal alanine aminotransferase levels.

@article{Bolacchi2006IncreasedHC,
  title={Increased hepatitis C virus (HCV)-specific CD4+CD25+ regulatory T lymphocytes and reduced HCV-specific CD4+ T cell response in HCV-infected patients with normal versus abnormal alanine aminotransferase levels.},
  author={Francesca Bolacchi and Anna Sinistro and Chiara Ciaprini and Flavio Demin and Marcella Capozzi and Francesca Ippolita Cal{\`o} Carducci and Cecilia M J Drapeau and Giovanni Rocchi and Alberto N Bergamini},
  journal={Clinical and experimental immunology},
  year={2006},
  volume={144 2},
  pages={188-96}
}
CD4+CD25+ T regulatory cells may play a role in the different clinical presentations of chronic hepatitis C virus (HCV) infection by suppressing CD4+ T cell responses. Peripheral CD4+CD25+ T cells from chronic HCV carriers with normal and abnormal alanine aminotransferase (ALT) were analysed for specificity and effect on HCV-specific CD4+ T cell reactivity by flow cytometry for intracellular cytokine production and proliferation assay. HCV-specific CD4+CD25(+high) T cells consistently produced… CONTINUE READING
56 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 56 extracted citations

Similar Papers

Loading similar papers…