Increased hepatic retinal dehydrogenase activity after phenobarbital and ethanol administration.

@article{Leo1989IncreasedHR,
  title={Increased hepatic retinal dehydrogenase activity after phenobarbital and ethanol administration.},
  author={Maria Anna Leo and C. I. Kim and N Lowe and Charles S. Lieber},
  journal={Biochemical pharmacology},
  year={1989},
  volume={38 1},
  pages={
          97-103
        }
}
Retinol forms retinoic acid via retinal.
Purification and partial characterization of a rat kidney aldehyde dehydrogenase that oxidizes retinal to retinoic acid.
TLDR
It is suggested that aldehyde dehydrogenase found in the kidney may be a specific retinal dehydrogen enzyme, involved in vitamin A metabolism.
Class IV alcohol/retinol dehydrogenase localization in epidermal basal layer: Potential site of retinoic acid synthesis during skin development
TLDR
Examining mouse skin for the expression of genes encoding class I ADH and class IV ADH, the only ADH isozymes in this species able to function as retinol dehydrogenases in vitro provides evidence that the basal layer of the epidermis may be the primary site of local retinoic acid synthesis needed for retinoid signaling in the skin.
Involvement of Alcohol-Metabolizing Enzymes in Retinoic Acid Synthesis and Inhibition by Ethanol
TLDR
The presently available evidence concerning the role of alcohol dehydrogenase in retinoic acid synthesis, the roles of retinooic acid in neural tube development, and therole of ethanol as an agent that can disrupt both retinoi acid synthesis and Neural tube development is described.
A hypothetical mechanism for fetal alcohol syndrome involving ethanol inhibition of retinoic acid synthesis at the alcohol dehydrogenase step.
  • G. Duester
  • Medicine
    Alcoholism, clinical and experimental research
  • 1991
TLDR
An hypothesis is presented in which many of the abnormalities observed in fetal alcohol syndrome may be caused by high levels of ethanol acting as a competitive inhibitor of ADH-catalyzed retinol oxidation in the embryo or fetus.
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