Increased hemoglobin O2 affinity does not improve O2 consumption in hypoxemia.

@article{Gutierrez1989IncreasedHO,
  title={Increased hemoglobin O2 affinity does not improve O2 consumption in hypoxemia.},
  author={Guillermo Gutierrez and J M Andry},
  journal={Journal of applied physiology},
  year={1989},
  volume={66 2},
  pages={837-43}
}
We perfused an isolated rabbit hindlimb preparation with suspensions of human erythrocytes (RBC) having different O2 affinities. Our objective was to compare the effect of changes in P50, the PO2 at which hemoglobin is 50% saturated, on tissue O2 consumption during severe hypoxemia. A high-affinity (HA) group (n = 9) was perfused with RBC incubated in NaCNO (P50 = 21.4 +/- 1.9 Torr). This was compared with a low-affinity (LA) group (n = 9) perfused with rejuvenated RBC (P50 = 31.1 +/- 1.8 Torr… CONTINUE READING

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