Increased heme oxygenase-1 gene expression in the livers of patients with portal hypertension due to severe hepatic cirrhosis.

@article{Matsumi2002IncreasedHO,
  title={Increased heme oxygenase-1 gene expression in the livers of patients with portal hypertension due to severe hepatic cirrhosis.},
  author={Masaki Matsumi and Takashi Takahashi and Hiroshi Fujii and Ichiro Ohashi and Ryuji Kaku and Hiroshi Nakatsuka and Hiroko Shimizu and Kiyoshi Morita and Masakazu Hirakawa and Mitsuhiro Inagaki and Hiroshi Sadamori and Takahito Yagi and Noriaki Tanaka and Reiko Akagi},
  journal={The Journal of international medical research},
  year={2002},
  volume={30 3},
  pages={282-8}
}
Surgical bleeding associated with splanchnic hyperaemia due to portal hypertension complicates the anaesthetic management of hepatic transplantation. Although the mechanism(s) of portal hypertension are not fully understood, carbon monoxide, a product of the heme oxygenase (HO) reaction, is thought to be one of the endogenous vasodilators in the liver. In this study, the expression of mRNA encoding inducible HO isozyme (HO-1) in the livers of patients with portal hypertension undergoing hepatic… CONTINUE READING