Increased heart rate variability in mice overexpressing the Cu/Zn superoxide dismutase.

@article{Thireau2008IncreasedHR,
  title={Increased heart rate variability in mice overexpressing the Cu/Zn superoxide dismutase.},
  author={J{\'e}r{\^o}me Thireau and Denise Poisson and Bei Li Zhang and Ludovic Gillet and Marie Le P{\'e}cheur and Christian Andr{\`e}s and Jacqueline London and Dominique Babuty},
  journal={Free radical biology & medicine},
  year={2008},
  volume={45 4},
  pages={396-403}
}
Cu/Zn superoxide dismutase (SOD1) is implicated in various pathological conditions including Down's syndrome, neurodegenerative diseases, and afflictions of the autonomic nervous system (ANS). To assess the SOD1 contribution to ANS dysfunction, especially its influence on cardiac regulation, we studied the heart rate variability (HRV) and cardiac arrhythmias in conscious 12-month-old male and female transgenic mice for the human SOD1 gene (TghSOD1). TghSOD1 mice presented heart rate reduction… CONTINUE READING

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