Increased growth of brown adipose tissue but its reduced thermogenic activity in creatine-depleted rats fed beta-guanidinopropionic acid.

@article{Yamashita1995IncreasedGO,
  title={Increased growth of brown adipose tissue but its reduced thermogenic activity in creatine-depleted rats fed beta-guanidinopropionic acid.},
  author={Hiroyuki Yamashita and Yoshinobu Ohira and Toshio Wakatsuki and Machiko Yamamoto and Takako Kizaki and Shuji Oh-ishi and Hideki Ohno},
  journal={Biochimica et biophysica acta},
  year={1995},
  volume={1230 1-2},
  pages={69-73}
}
To study the responses of thermogenic activity in brown adipose tissue (BAT) to creatine depletion, male Wistar rats were fed creatine analogue beta-guanidinopropionic acid (beta-GPA) for about 10 weeks. Compared to control rats, a marked decrease in the levels of high-energy phosphates, such as phosphocreatine and ATP, was noted in BAT of beta-GPA rats. Conversely, upward trends in other chemical components (DNA, glycogen, and total protein) in BAT as well as an increase in BAT mass were… CONTINUE READING
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