Increased glucose uptake and oxidation in mouse hearts prevent high fatty acid oxidation but cause cardiac dysfunction in diet-induced obesity.

@article{Yan2009IncreasedGU,
  title={Increased glucose uptake and oxidation in mouse hearts prevent high fatty acid oxidation but cause cardiac dysfunction in diet-induced obesity.},
  author={Jie Yan and Martin Elliot Young and Lei Cui and Gary D Lopaschuk and Ronglih Liao and Rong Tian},
  journal={Circulation},
  year={2009},
  volume={119 21},
  pages={2818-28}
}
BACKGROUND Shift of myocardial substrate preference has been observed in many chronic diseases such as diabetes and heart failure. This study was undertaken to elucidate the mechanisms underlying the chronic substrate switch in adult hearts and to determine the functional consequences of the switch. METHODS AND RESULTS Transgenic mice with cardiac-specific overexpression of the insulin-independent glucose transporter GLUT1 (TG) were used to increase intracellular glucose in cardiac myocytes… CONTINUE READING