Increased glomerular and extracellular malondialdehyde levels in patients and rats with focal segmental glomerulosclerosis.

@article{Kuo2005IncreasedGA,
  title={Increased glomerular and extracellular malondialdehyde levels in patients and rats with focal segmental glomerulosclerosis.},
  author={H-T Kuo and M-c Kuo and Y-W Chiu and J Chang and J-Y Guh and H Chen},
  journal={European journal of clinical investigation},
  year={2005},
  volume={35 4},
  pages={245-50}
}
BACKGROUND Evidence suggests an increase in oxidative stress in patients with chronic kidney disease, as glomerulosclerosis is the prerequisite for chronic kidney disease; whether the oxidative stress already exists early on is not known. MATERIALS AND METHODS In this study we measured the plasma and urinary levels of malondialdehyde (MDA), the end product of lipid peroxidation, and assessed the immunoreactivity of MDA and superoxide dismutase (SOD) in glomeruli of patients and rats with… CONTINUE READING