Increased global integration in the brain after psilocybin therapy for depression

  title={Increased global integration in the brain after psilocybin therapy for depression},
  author={Richard E. Daws and Christopher Timmermann and Bruna Giribaldi and James D Sexton and Matthew B. Wall and David Erritzoe and Leor Roseman and David J. Nutt and Robin Lester Carhart-Harris},
  journal={Nature Medicine},
Psilocybin therapy shows antidepressant potential, but its therapeutic actions are not well understood. We assessed the subacute impact of psilocybin on brain function in two clinical trials of depression. The first was an open-label trial of orally administered psilocybin (10 mg and 25 mg, 7 d apart) in patients with treatment-resistant depression. Functional magnetic resonance imaging (fMRI) was recorded at baseline and 1 d after the 25-mg dose. Beck’s depression inventory was the primary… 
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