Increased global integration in the brain after psilocybin therapy for depression

@article{Daws2022IncreasedGI,
  title={Increased global integration in the brain after psilocybin therapy for depression},
  author={Richard E. Daws and Christopher Timmermann and Bruna Giribaldi and James D Sexton and Matthew B. Wall and David Erritzoe and Leor Roseman and David J. Nutt and Robin Lester Carhart-Harris},
  journal={Nature Medicine},
  year={2022},
  volume={28},
  pages={844-851}
}
Psilocybin therapy shows antidepressant potential, but its therapeutic actions are not well understood. We assessed the subacute impact of psilocybin on brain function in two clinical trials of depression. The first was an open-label trial of orally administered psilocybin (10 mg and 25 mg, 7 d apart) in patients with treatment-resistant depression. Functional magnetic resonance imaging (fMRI) was recorded at baseline and 1 d after the 25-mg dose. Beck’s depression inventory was the primary… 
Unraveling the Mysteries of Mental Illness With Psilocybin
TLDR
A review of studies in the last two years that suggest psilocybin promotes neuronal plasticity, which may lead to changes in brain network connectivity and evidence that this ancient molecule can promote functionally connected intrinsic networks in the human brain, resulting in durable improvements in the severity of depressive symptoms.
Dysfunctional cortical gradient topography in treatment resistant major depression
Background Treatment-Resistant Depression (TRD) refers to patients with major depressive disorder who do not remit after two or more antidepressant trials. TRD is common and highly debilitating, but
Electrical spiking of psilocybin fungi
TLDR
This short analysis provides a proof of intrinsic electrical communication in psilocybin fungi, and further establishes these fungi as a valuable tool for studying fungal electro-physiology.
High-Resolution Spatiotemporal Analysis of Single Serotonergic Axons in an In Vitro System
TLDR
Serotonergic axon walks in neural tissue may strongly reflect the stochastic geometry of this tissue and the proposed experimental platform can support next-generation analyses of the serotonergic matrix, including seamless integration with supercomputing approaches.
Brain Serotonergic Fibers Suggest Anomalous Diffusion-Based Dropout in Artificial Neural Networks
TLDR
It is proposed that the brain serotonergic fibers meet some of the expected criteria because of their ubiquitous presence, stochastic structure, and ability to grow throughout the individual’s lifespan.
Neuroimaging Correlates of Treatment Response with Psychedelics in Major Depressive Disorder: A Systematic Review
Preliminary evidence supports the use of psychedelics for major depressive disorder (MDD). However, less attention has been given to the neural mechanisms behind their effects. We conducted a
Probing the antidepressant action of psychedelics.

References

SHOWING 1-10 OF 59 REFERENCES
Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms
TLDR
The post-treatment brain changes are different to previously observed acute effects of psilocybin and other ‘psychedelics’ yet were related to clinical outcomes, and a ‘reset’ therapeutic mechanism is proposed.
Emotions and brain function are altered up to one month after a single high dose of psilocybin
TLDR
It is suggested that psilocybin may increase emotional and brain plasticity, and the reported findings support the hypothesis that negative affect may be a therapeutic target for p silocybin.
More Realistic Forecasting of Future Life Events After Psilocybin for Treatment-Resistant Depression
TLDR
It is suggested that psilocybin with psychological support might correct pessimism biases in patients with treatment-resistant depression, enabling a more positive and accurate outlook.
Subacute effects of the psychedelic ayahuasca on the salience and default mode networks
Background: Neuroimaging studies have just begun to explore the acute effects of psychedelics on large-scale brain networks’ functional organization. Even less is known about the neural correlates of
Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin
TLDR
Psilocybin caused a significant decrease in the positive coupling between the mPFC and PCC, which strongly imply that the subjective effects of psychedelic drugs are caused by decreased activity and connectivity in the brain's key connector hubs, enabling a state of unconstrained cognition.
Effect of treatments for depression on quality of life: a meta-analysis*
TLDR
CBT and SSRIs for depression were both associated with moderate improvements in QOL, but are possibly caused by different mechanisms.
Patients’ Accounts of Increased “Connectedness” and “Acceptance” After Psilocybin for Treatment-Resistant Depression
TLDR
It is suggested that psilocybin treatment for depression may work via paradigmatically novel means, antithetical to antidepressant medications, and some short-term talking therapies.
Psychedelics and the essential importance of context
TLDR
This article highlights the pharmacological mechanisms of classic psychedelics that it is believed render their effects exceptionally sensitive to context, and develops an evidence base for long-held assumptions about the critical importance of context in relation to psychedelic use that can help minimise harms and maximise potential benefits.
The Current Status of Psychedelics in Psychiatry.
TLDR
The discovery by Griffiths et al that a single high dose of psilocybin, given in a psychotherapeutic setting, produced enduring positive changes in mood and wellbeing in people who do not have depression suggested the possible utility of p silocybin for treating depression and initiated the launch of studies in the UK and US that further supported an antidepressant outcome.
...
...