Increased glial glutamate transporter EAAT2 expression reduces visceral nociceptive response in mice.

@article{Lin2009IncreasedGG,
  title={Increased glial glutamate transporter EAAT2 expression reduces visceral nociceptive response in mice.},
  author={Yuan Lin and Guilian Tian and Kenny Roman and Chalonda R. Handy and Joseph B. Travers and Chien-liang Glenn Lin and Robert Louis Stephens},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2009},
  volume={296 1},
  pages={G129-34}
}
Visceral hypersensitivity is the leading complaint of functional bowel disorders. Central sensitization mediated by glutamate receptor activation is implicated in pathophysiology of visceral pain. The glial glutamate transporter EAAT2 is the principal mediator of glutamate clearance to terminate glutamate-mediated responses. Transgenic mice overexpressing human EAAT2 (EAAT2 mice), which exhibited a twofold enhanced glutamate uptake, showed 39% less writhing response to intraperitoneal acetic… CONTINUE READING

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