Increased genomic instability in somatic cells of the progeny of female mice exposed to acute X-radiation in the preconceptional period
@article{Lomaeva2011IncreasedGI, title={Increased genomic instability in somatic cells of the progeny of female mice exposed to acute X-radiation in the preconceptional period}, author={M. G. Lomaeva and G. V. Vasil’eva and L. A. Fomenko and Valeriya N. Antipova and Azhub I. Gaziev and Vladimir G Bezlepkin}, journal={Russian Journal of Genetics}, year={2011}, volume={47}, pages={1221-1226} }
The level of genome instability (GI) was studied in the progeny of female mice exposed in the preconceptional period to radiation doses of 0.5, 1, and 2 Gy in comparison to that in the progeny of the same parent pairs born before irradiation of the females. To assess the level of genome instability, we analyzed polymorphism of DNA fragments from postmitotic (blood and brain) and proliferating (spleen and tail tip) tissues amplified by AP-PCR (PCR amplification with an arbitrary primer). It was…
4 Citations
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GelAnalyzer software, which is used to identify and correctly compare DNA fingerprints consisting of a large number of discrete bands, has been developed by the project to study the quantitative…
References
SHOWING 1-10 OF 48 REFERENCES
[Transgenerational transmission of radiation induced genomic instability].
- BiologyRadiatsionnaia biologiia, radioecologiia
- 2006
For the estimation of pathogenic role of radiation induced genomic instability in humans, particularly in children of exposed parents the parallel study of the same human cohorts using clinical parameters and various characteristic of genomic instability seems to be very important.
Transgenerational transmission of radiation induced genomic instability
- Biology
- 2006
For the estimation of pathogenic role of radiation induced genomic instability in humans, particularly in children of exposed parents the parallel study of the same human cohorts using clinical parameters and various characteristic of genomic instability seems to be very important.
[The increase in the variability of microsatellite-associated repeats in the genome of gamma-irradiated male mice is tissue specific].
- BiologyRadiatsionnaia biologiia, radioecologiia
- 2004
A tissue-specific character of transmission of radiation-induced alterations in the genome of germ cells of male parents to the somatic cells of the progeny is suggested.
AP-PCR assay of DNA alterations in the progeny of male mice exposed to low-level γ-radiation
- Biology
- 2001
Transgenerational genomic instability in children of irradiated parents as a result of the Chernobyl Nuclear Accident.
- MedicineMutation research
- 2009
Transgenerational transmission of radiation damage: genomic instability and congenital malformation.
- MedicineJournal of radiation research
- 2006
Late radiation effects seem to have similar patterns as observed in non-exposed subjects, however, the rates are increased after irradiation.
Frequency and nature of specific-locus mutations induced in female mice by radiations and chemicals: a review.
- BiologyMutation research
- 1992
Stage-dependent variation in the radiosensitivity of DNA in developing male germ cells.
- BiologyRadiation research
- 1990
The induction and rejoining of gamma-ray-induced DNA single-strand breaks (SSBs) were measured in the spermatogenic cells of mice using the alkaline elution technique to examine selectively cohorts of radiolabeled cells in the successive stages of maturation.
[Genetic consequences of irradiation of one or both parents (results of experiments on Wistar rats) Exitus lethalis in Wistar rat's progeny after irradiation of one or both parents].
- MedicineRadiatsionnaia biologiia, radioecologiia
- 2001
The increase in radiation effects in the F1 due to the mating of two irradiated parents appears to be associated with a mechanism demonstrating additivity or synergism.
[Genetic consequences of irradiation of one or both parents (results of experiments on Wistar rats) Exitus lethalis in Wistar rat's progeny after irradiation of one or both parents].
- Medicine
- 2001
The increase in radiation effects in the F1 due to the mating of two irradiated parents appears to be associated with a mechanism demonstrating additivity or synergism.