Increased genomic instability in somatic cells of the progeny of female mice exposed to acute X-radiation in the preconceptional period

@article{Lomaeva2011IncreasedGI,
  title={Increased genomic instability in somatic cells of the progeny of female mice exposed to acute X-radiation in the preconceptional period},
  author={M. G. Lomaeva and G. V. Vasil’eva and L. A. Fomenko and Valeriya N. Antipova and Azhub I. Gaziev and Vladimir G Bezlepkin},
  journal={Russian Journal of Genetics},
  year={2011},
  volume={47},
  pages={1221-1226}
}
The level of genome instability (GI) was studied in the progeny of female mice exposed in the preconceptional period to radiation doses of 0.5, 1, and 2 Gy in comparison to that in the progeny of the same parent pairs born before irradiation of the females. To assess the level of genome instability, we analyzed polymorphism of DNA fragments from postmitotic (blood and brain) and proliferating (spleen and tail tip) tissues amplified by AP-PCR (PCR amplification with an arbitrary primer). It was… 
4 Citations
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