Increased generation of Foxp3(+) regulatory T cells by manipulating antigen presentation in the thymus.

@article{Lin2016IncreasedGO,
  title={Increased generation of Foxp3(+) regulatory T cells by manipulating antigen presentation in the thymus.},
  author={Jiqiang Lin and Lu Yang and Hernandez Moura Silva and Alissa Trzeciak and Yongwon Choi and Susan R Schwab and Michael L. Dustin and Juan Jose Lafaille},
  journal={Nature communications},
  year={2016},
  volume={7},
  pages={10562}
}
Regulatory T-cell (Treg) selection in the thymus is essential to prevent autoimmune diseases. Although important rules for Treg selection have been established, there is controversy regarding the degree of self-reactivity displayed by T-cell receptors expressed by Treg cells. In this study we have developed a model of autoimmune skin inflammation, to determine key parameters in the generation of skin-reactive Treg cells in the thymus (tTreg). tTreg development is predominantly AIRE dependent… CONTINUE READING
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size, diversity, and cellular composition

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