Increased gastric and intestinal permeability in patients with Crohn's disease.

  title={Increased gastric and intestinal permeability in patients with Crohn's disease.},
  author={J F Wyatt and Georg Oberhuber and Stephan Pongratz and Andreas P{\"u}sp{\"o}k and Gabriele Moser and Gottfried Novacek and Herbert Lochs and Harald Vogelsang},
  journal={The American journal of gastroenterology},
  volume={92 10},
OBJECTIVES Patients with Crohn's disease exhibit marked changes in intestinal permeability that can be assessed by lactulose and mannitol. Sucrose is a novel marker for gastric permeability. We combined these three sugars to investigate whether patients with Crohn's disease demonstrate changes in gastric permeability and if so, whether these changes are matched with altered intestinal permeability. METHODS Fifty patients with Crohn's disease and 30 healthy subjects each drank a solution… CONTINUE READING

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