Increased frequency of the null allele at the complement C4b locus in autism.

@article{Warren1991IncreasedFO,
  title={Increased frequency of the null allele at the complement C4b locus in autism.},
  author={Reed P. Warren and Vijendra K. Singh and Phyllis Cole and J. Dennis Odell and Carmen B. Pingree and William L. Warren and Eileen White},
  journal={Clinical and experimental immunology},
  year={1991},
  volume={83 3},
  pages={438-40}
}
Associations between C4 deficiency and autoimmune disorders have been found over the past several years. Since autism has several autoimmune features, the frequencies of null (no protein produced) alleles at the C4A and C4B loci were studied in 19 subjects with autism and their family members. The autistic subjects and their mothers had significantly increased phenotypic frequencies of the C4B null allele (58% in both the autistic subjects and mothers, compared with 27% in control subjects… CONTINUE READING

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