Increased frequency of the k-ras G12C mutation in MYH polyposis colorectal adenomas

@article{Jones2004IncreasedFO,
  title={Increased frequency of the k-ras G12C mutation in MYH polyposis colorectal adenomas},
  author={Suzanne Jones and Sally Lambert and Geraint T. Williams and Jacqueline M Best and Julian R. Sampson and Jeremy P. Cheadle},
  journal={British Journal of Cancer},
  year={2004},
  volume={90},
  pages={1591 - 1593}
}
Colorectal tumours from MYH polyposis patients display an excess of somatic G : C → T : A transversions in the adenomatous polyposis coli gene. Here, we identify k-ras mutations in nine out of 54 (16.7%) MYH polyposis tumours. Their presence was associated with increased dysplasia and tubulovillous morphology (P=0.005). G : C → T : A transversions in k-ras were significantly more frequent in MYH polyposis adenomas than in sporadic or familial adenomatous polyposis-associated tumours (P⩽0.002… CONTINUE READING

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