Increased frequency of myeloid-derived suppressor cells during active tuberculosis and after recent mycobacterium tuberculosis infection suppresses T-cell function.

@article{Plessis2013IncreasedFO,
  title={Increased frequency of myeloid-derived suppressor cells during active tuberculosis and after recent mycobacterium tuberculosis infection suppresses T-cell function.},
  author={Nelita du Plessis and Laurianne Loebenberg and Magdalena Kriel and Florian von Groote-Bidlingmaier and Eliana Ribechini and Andre Gareth Loxton and Paul D van Helden and Manfred B Lutz and Gerhard Walzl},
  journal={American journal of respiratory and critical care medicine},
  year={2013},
  volume={188 6},
  pages={724-32}
}
RATIONALE Inadequacy of T-cell responses may result in the development of tuberculosis (TB). Myeloid-derived suppressor cells (MDSCs) have been described as suppressors of T-cell function in cancer biology and recently in several infectious diseases. OBJECTIVES To explore the presence and role of MDSCs in TB. METHODS We analyzed surface markers of MDSCs in peripheral blood and at the site of disease in TB cases and in patients with lung cancer, and in peripheral blood of asymptomatic… CONTINUE READING
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