Increased frequency of homologous recombination and T-DNA integration in Arabidopsis CAF-1 mutants.

  title={Increased frequency of homologous recombination and T-DNA integration in Arabidopsis CAF-1 mutants.},
  author={Masaki Endo and Yuichi Ishikawa and Keishi Osakabe and Shigeki Nakayama and Hidetaka Kaya and Takashi Araki and Kei-ichi Shibahara and Kiyomi Abe and Hiroaki Ichikawa and Lisa Valentine and Barbara B. Hohn and Seiichi Toki},
  journal={The EMBO journal},
  volume={25 23},
Chromatin assembly factor 1 (CAF-1) is involved in nucleo some assembly following DNA replication and nucleotide excision repair. In Arabidopsis thaliana, the three CAF-1 subunits are encoded by FAS1, FAS2 and, most likely, MSI1, respectively. In this study, we asked whether genomic stability is altered in fas1 and fas2 mutants that are lacking CAF-1 activity. Depletion of either subunit increased the frequency of somatic homologous recombination (HR) in planta approximately 40-fold. The… CONTINUE READING
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