Increased frequency of circulating follicular helper T cells in lupus patients is associated with autoantibody production in a CD40L-dependent manner.

@article{Xu2015IncreasedFO,
  title={Increased frequency of circulating follicular helper T cells in lupus patients is associated with autoantibody production in a CD40L-dependent manner.},
  author={Huaheng Xu and Jing Liu and Xin Cui and Yanhua Zuo and Zongfang Zhang and Yanxia Li and Ran Tao and Ying Li and Jie Pang},
  journal={Cellular immunology},
  year={2015},
  volume={295 1},
  pages={
          46-51
        }
}
This study was to determine the frequency of circulating follicular helper T (Tfh) cells in patients with systemic lupus erythematosus (SLE) and investigate the relationship between Tfh cells and autoantibody production. An increased frequency of circulating Tfh cells was found in SLE patients, and there were positive co-relationship between Tfh cells and SLEDAI, serum IgG, Anti-nuclear antibody titers and anti-dsDNA (P=0.0004, 0.0006, 0.0237, 0.0000, respectively). B cells sorted from SLE… CONTINUE READING

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