Increased frequency of TP53 mutations in BRCA1 and BRCA2 ovarian tumours.

@article{Ramus1999IncreasedFO,
  title={Increased frequency of TP53 mutations in BRCA1 and BRCA2 ovarian tumours.},
  author={Susan J Ramus and Linda Bobrow and Paul P. D. Pharoah and Damon S. Finnigan and A. Ya . Fishman and Marco M. Altaras and Patricia A. Harrington and Simon A. Gayther and Bruce A. Ponder and Lori S. Friedman},
  journal={Genes, chromosomes & cancer},
  year={1999},
  volume={25 2},
  pages={
          91-6
        }
}
We screened 81 ovarian tumours (30 BRCA1 associated, 18 BRCA2 associated, and 33 sporadic) for somatic TP53 mutations using both DNA analysis and immunostaining. TP53 mutations were significantly more frequent in tumours with mutations in BRCA1 (70% by immunostaining and 60% by DNA analysis) and BRCA2 (67% and 50%) compared to sporadic controls (39% and 30%) (P = 0.009). A higher proportion of tumours with BRCA1 and BRCA2 mutations were poorly differentiated, and TP53 mutant tumours in all… CONTINUE READING
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