Increased frequency and clinical significance of myeloid-derived suppressor cells in human colorectal carcinoma.

@article{Sun2012IncreasedFA,
  title={Increased frequency and clinical significance of myeloid-derived suppressor cells in human colorectal carcinoma.},
  author={Hongli Sun and Xin Zhou and Yi-Feng Xue and Ke Wang and Yun-feng Shen and Jing-Jue Mao and Hong-feng Guo and Zong-Ning Miao},
  journal={World journal of gastroenterology},
  year={2012},
  volume={18 25},
  pages={3303-9}
}
AIM To investigate the frequency and clinical significance of the myeloid-derived suppressor cells (MDSC) in human colorectal carcinoma (CRC). METHODS Samples of peripheral blood and tumor tissue from 49 CRC patients were analyzed. Mononuclear cells were isolated by Ficoll-Hypaque density gradient centrifugation and were subjected to a flow cytometry-based immunophenotypic analysis. RESULTS A considerable increase in the percentage of CD33⁺HLA-DR⁻ MDSCs was observed in the peripheral blood… CONTINUE READING
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