Increased frequency and broadened specificity of latent EBV nuclear antigen-1-specific T cells in multiple sclerosis.

@article{Lnemann2006IncreasedFA,
  title={Increased frequency and broadened specificity of latent EBV nuclear antigen-1-specific T cells in multiple sclerosis.},
  author={Jan D L{\"u}nemann and Nancy Edwards and Paolo A Muraro and Sumiko Hayashi and Jeffrey I. Cohen and Christian M{\"u}nz and Roland Dr Martin},
  journal={Brain : a journal of neurology},
  year={2006},
  volume={129 Pt 6},
  pages={
          1493-506
        }
}
Epidemiological studies consistently demonstrate that patients with multiple sclerosis are almost universally infected with Epstein-Barr virus (EBV) and that the risk of developing the disease increases with the level of EBV-specific antibody titers. The EBV-encoded nuclear antigen-1 (EBNA1) maintains the viral episome in replicating infected human B cells, and EBNA1-specific CD4+ T cells have been identified as a crucial part of the EBV-specific immune control in healthy individuals. We… CONTINUE READING

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