Increased fragmentation of sleep-wake cycles in the 5XFAD mouse model of Alzheimer’s disease

@inproceedings{Sethi2015IncreasedFO,
  title={Increased fragmentation of sleep-wake cycles in the 5XFAD mouse model of Alzheimer’s disease},
  author={Mansi Sethi and Shreyas S. Joshi and Robin L. Webb and Tina L. Beckett and Kevin D. Donohue and Michael P Murphy and Bruce F. O’Hara and Marilyn J. Duncan},
  booktitle={Neuroscience},
  year={2015}
}
Sleep perturbations including fragmented sleep with frequent night-time awakenings and daytime naps are common in patients with Alzheimer's disease (AD), and these daily disruptions are a major factor for institutionalization. The objective of this study was to investigate if sleep-wake patterns are altered in 5XFAD mice, a well-characterized double… CONTINUE READING