Increased formation of S-nitrothiols and nitrotyrosine in cirrhotic rats during endotoxemia.

  title={Increased formation of S-nitrothiols and nitrotyrosine in cirrhotic rats during endotoxemia.},
  author={Lone Harild Ottesen and David Harry and Michael Frost and Susan Davies and Khalil Khan and Barry Halliwell and Katy Moore},
  journal={Free radical biology & medicine},
  volume={31 6},
Plasma S-nitrosothiols are believed to function as a circulating form of nitric oxide that affects both vascular function and platelet aggregation. However, the formation of circulating S-nitrosothiols in relation to acute and chronic disease is largely unknown. Plasma S-nitrosothiols were measured by chemiluminescence in rats with biliary cirrhosis or controls, and the effect of lipopolysaccharide (LPS) on their formation was determined. Plasma S-nitrosothiols were increased in rats with… CONTINUE READING


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