Increased fitness of drug resistant HIV-1 protease as a result of acquisition of compensatory mutations during suboptimal therapy.

@article{Nijhuis1999IncreasedFO,
  title={Increased fitness of drug resistant HIV-1 protease as a result of acquisition of compensatory mutations during suboptimal therapy.},
  author={Monique Nijhuis and Rob Schuurman and Dorien de Jong and Jennica Erickson and Elena Gustchina and Jan Albert and Pauline Schipper and Sergei V. Gulnik and Charles A. Boucher},
  journal={AIDS},
  year={1999},
  volume={13 17},
  pages={2349-59}
}
OBJECTIVE It is thought as a consequence of continuous replication, HIV-1 has acquired an optimal fitness state and that suboptimal antiretroviral therapy selects for drug resistant variants which show impaired fitness in the absence of the drug. In this paper we studied the evolution and fitness of viral populations appearing in a patient who received protease monotherapy. METHODS Two factors contributing to fitness, drug resistance and protease catalytic activity, were studied at the… CONTINUE READING

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