Increased filaggrin-metabolizing enzyme activity in atopic skin: a pilot study using a canine model of atopic dermatitis.

Abstract

BACKGROUND Filaggrin (FLG) and its metabolites are essential for skin barrier function and hydration of the stratum corneum. Alteration of the FLG metabolism could be the basis for an abnormal skin barrier in allergic dogs. OBJECTIVES To investigate the expression and distribution of calpain-1, caspase-14, furin and matriptase, four enzymes involved in… (More)
DOI: 10.1111/vde.12443

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