Increased fibrosis progression rates in hepatitis C patients carrying the prothrombin G20210A mutation.

@article{Maharshak2011IncreasedFP,
  title={Increased fibrosis progression rates in hepatitis C patients carrying the prothrombin G20210A mutation.},
  author={Nitsan Maharshak and Philippe Halfon and Varda Deutsch and Hava Peretz and Shlomo Berliner and Sigal Fishman and Shira Zelber-Sagi and Uri Rozovski and Moshe M Leshno and Ran Oren},
  journal={World journal of gastroenterology},
  year={2011},
  volume={17 45},
  pages={5007-13}
}
AIM To examine whether hepatitis C virus (HCV)-infected patients who carry hypercoagulable mutations suffer from increased rates of liver fibrosis. METHODS We analyzed DNA samples of 168 HCV patients for three common hypercoagulable gene mutations: prothrombin 20210 (PT20210), factor V Leiden (FV Leiden) and methylene tetrahydrofolate reductase (MTHFR). The patients were consecutively recruited as part of the prospective "Fibroscore Study" in France. The effect of the various mutations on the… CONTINUE READING
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