Increased fetal DNA concentrations in the plasma of pregnant women carrying fetuses with trisomy 21.

@article{Lo1999IncreasedFD,
  title={Increased fetal DNA concentrations in the plasma of pregnant women carrying fetuses with trisomy 21.},
  author={Yuk Ming Dennis Lo and Tze kin Lau and J Zhang and Tse Ngong Leung and A M Chang and Nils Magnus Hjelm and R. Sarah Elmes and Diana W. Bianchi},
  journal={Clinical chemistry},
  year={1999},
  volume={45 10},
  pages={
          1747-51
        }
}
BACKGROUND The recent discovery of the presence of circulating cell-free fetal DNA in maternal plasma opens up new prenatal diagnostic applications and provides new avenues for clinical investigation. It is of research and potential diagnostic interest to determine whether fetal trisomy 21 may be associated with quantitative abnormalities of circulating fetal DNA in maternal plasma. METHODS Maternal plasma samples were prospectively collected from two centers situated in Hong Kong and Boston… 

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