Increased fat accumulation in liver may link insulin resistance with subcutaneous abdominal adipocyte enlargement, visceral adiposity, and hypoadiponectinemia in obese individuals.

@article{Koka2008IncreasedFA,
  title={Increased fat accumulation in liver may link insulin resistance with subcutaneous abdominal adipocyte enlargement, visceral adiposity, and hypoadiponectinemia in obese individuals.},
  author={Juraj Ko{\vs}ka and Norbert Stefan and Paska A. Permana and Christian Weyer and Mina Sonoda and Clifton Bogardus and Steven R. Smith and Denis R. Joanisse and Tohru Funahashi and Jonathan Krakoff and Joy C. Bunt},
  journal={The American journal of clinical nutrition},
  year={2008},
  volume={87 2},
  pages={295-302}
}
BACKGROUND Enlargement of adipocytes from subcutaneous abdominal adipose tissue (SAT), increased intrahepatic lipid content (IHL), intramyocellular lipid content (IMCL), and low circulating adiponectin concentrations are associated with insulin resistance. OBJECTIVE Because adiponectin increases fat oxidation in skeletal muscle and liver, and the expression of the adiponectin gene in SAT is inversely associated with adipocyte size, we hypothesized that hypoadiponectinemia links hypertrophic… CONTINUE READING

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