Increased fMRI responses during encoding in mild cognitive impairment.

  title={Increased fMRI responses during encoding in mild cognitive impairment.},
  author={Anne H{\"a}m{\"a}l{\"a}inen and Maija Pihlajam{\"a}ki and Heikki Tanila and Tuomo H{\"a}nninen and Eini Niskanen and Susanna Tervo and Pasi A. Karjalainen and Ritva L. Vanninen and Hilkka Soininen},
  journal={Neurobiology of aging},
  volume={28 12},
Structural and functional magnetic resonance imaging (fMRI) was performed on 21 healthy elderly controls, 14 subjects with mild cognitive impairment (MCI) and 15 patients with mild Alzheimer's disease (AD) to investigate changes in fMRI activation in relation to underlying structural atrophy. The fMRI paradigm consisted of associative encoding of novel picture-word pairs. Structural analysis of the brain was performed using voxel-based morphometry (VBM) and hippocampal volumetry. Compared to… CONTINUE READING