Increased expression of water channel aquaporin 1 and aquaporin 4 in Creutzfeldt-Jakob disease and in bovine spongiform encephalopathy-infected bovine-PrP transgenic mice

@article{Rodrguez2006IncreasedEO,
  title={Increased expression of water channel aquaporin 1 and aquaporin 4 in Creutzfeldt-Jakob disease and in bovine spongiform encephalopathy-infected bovine-PrP transgenic mice},
  author={Arciniegas Rodr{\'i}guez and Esther P{\'e}rez-Gracia and Juan Carlos Espinosa and Mart{\'i} Batlle Pumarola and Juan Maria Torres and Isidro Ferrer},
  journal={Acta Neuropathologica},
  year={2006},
  volume={112},
  pages={573-585}
}
Spongiform change is a cardinal feature in transmissible spongiform encephalopathies, including Creutzfeldt-Jakob disease (CJD) and bovine spongiform encephalopathy (BSE). It is characterized by swelling of the neuronal processes and vacuolization of the neuropil, leading to increased intraneuronal water content. The present study examines, by gel electrophoresis and Western blotting, the expression levels of the water channels aquaporin 1 (AQP1) and aquaporin 4 (AQP4) in the frontal cortex… CONTINUE READING
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